Manic-Depressive Illness: Linkage with the Xg Blood Group
RONALD R. FIEVE M.D.1,
JULIEN MENDLEWICZ M.D.2, , and
JOSEPH L. FLEISS PH.D.3
1 Chief of Psychiatric Research, Department of Internal Medicine, and Director of the Lithium Clinic, New York State Psychiatric Institute, 722 West 168th St., New York, N.Y. 10032 and Professor of Clinical Psychiatry, Columbia University
2 Visiting Psychiatrist, Department of Medical Genetics, New York State Psychiatric Institute, 722 West 168th St., New York, N.Y. 10032 and Research Associate in Psychiatry, Columbia University
3 Research Scientist, Department of Biometrics, New York State Department of Mental Hygiene, New York, N.Y. and Associate Professor of Biostatistics, Columbia University
Manic-depressive illness and the Xg blood group, a genetic marker located on the X chromosome, showed measurable linkage in successive generations of six families. These data suggest that a dominant X-linked factor is involved in the transmission of manic-depressive illness within the families studied.
