Am J Psychiatry 130:1088-1093, October 1973
doi: 10.1176/appi.ajp.130.10.1088
© 1973 American Psychiatric Association
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Evolving Behavior in the Clinical and Experimental Amphetamine (Model) Psychosis
EVERETT H. ELLINWOOD JR. M.D.1,
ABRAHAM SUDILOVSKY M.D.2, , and
LINDA M. NELSON 3
1 Director and Professor of Psychiatry, Behavioral Neuropharmacology Section, Department of Psychiatry, Duke University Medical Center, Durham, N.C. 27710
2 Research Associate, Behavioral Neuropharmacology Section, Department of Psychiatry, Duke University Medical Center, Durham, N.C. 27710
3 Senior Research Technician, Behavioral Neuropharmacology Section, Department of Psychiatry, Duke University Medical Center, Durham, N.C. 27710
A parallel is drawn between several behavioral constellations observed in the evolution of the human amphetamine psychosis and the motor-postural-attitudinal manifestations induced in animals by chronic amphetamine intoxication. On the basis of the results reported, a triple-layered model of psychosis is suggested and the roles played by participating neurotransmitters and mechanisms are further elaborated.
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