Amphetamine Psychosis: A "Model" Schizophrenia Mediated by Catecholamines

¹ Professor of Psychiatry and Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Md. 21205

Because of its close clinical similarity to acute paranoid schizophrenia, amphetamine psychosis may serve as a useful experimental model for schizophrenia. Molecular and clinical studies suggest that both the schizophrenia-like symptoms of amphetamine psychosis and the specific ability of phenothiazines to relieve the symptoms of schizophrenia and amphetamine psychosis may be the result of interactions with dopamine systems in the brain. The author discusses some implications of the roles dopamine and norepinephrine may play in mediating some schizophrenic symptoms.

This article has been cited by other articles:

				R. G. Ross Psychotic and Manic-like Symptoms During Stimulant Treatment of Attention Deficit Hyperactivity Disorder Am J Psychiatry, July 1, 2006; 163(7): 1149 - 1152. [Full Text] [PDF]

				T. G. Schulze, S. Ohlraun, P. M. Czerski, J. Schumacher, L. Kassem, M. Deschner, M. Gross, M. Tullius, V. Heidmann, S. Kovalenko, et al. Genotype-Phenotype Studies in Bipolar Disorder Showing Association Between the DAOA/G30 Locus and Persecutory Delusions: A First Step Toward a Molecular Genetic Classification of Psychiatric Phenotypes Am J Psychiatry, November 1, 2005; 162(11): 2101 - 2108. [Abstract] [Full Text] [PDF]

				P. Svenningsson, E. T. Tzavara, R. Carruthers, I. Rachleff, S. Wattler, M. Nehls, D. L. McKinzie, A. A. Fienberg, G. G. Nomikos, and P. Greengard Diverse Psychotomimetics Act Through a Common Signaling Pathway Science, November 21, 2003; 302(5649): 1412 - 1415. [Abstract] [Full Text] [PDF]

				L. Zhang and R. A. Warren Muscarinic and Nicotinic Presynaptic Modulation of EPSCs in the Nucleus Accumbens During Postnatal Development J Neurophysiol, December 1, 2002; 88(6): 3315 - 3330. [Abstract] [Full Text] [PDF]

				R. G. Johnson, K. E. Stevens, and G. M. Rose 5-Hydroxytryptamine2 Receptors Modulate Auditory Filtering in the Rat J. Pharmacol. Exp. Ther., May 1, 1998; 285(2): 643 - 650. [Abstract] [Full Text]

				P. O'Donnell, A. Lavin, L. W. Enquist, A. A. Grace, and J. P. Card Interconnected Parallel Circuits between Rat Nucleus Accumbens and Thalamus Revealed by Retrograde Transynaptic Transport of Pseudorabies Virus J. Neurosci., March 15, 1997; 17(6): 2143 - 2167. [Abstract] [Full Text] [PDF]

				D. Wong, H. Wagner Jr, L. Tune, R. Dannals, G. Pearlson, J. Links, C. Tamminga, E. Broussolle, H. Ravert, A. Wilson, et al. Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics Science, December 19, 1986; 234(4783): 1558 - 1563. [Abstract] [PDF]

				D. S. SEGAL, S. B. WEINBERGER, J. CAHILL, and S. J. MCCUNNEY Multiple Daily Amphetamine Administration: Behavioral and Neurochemical Alterations Science, February 22, 1980; 207(4433): 904 - 907. [Abstract] [PDF]

				N. Bacopoulos, E. Spokes, E. Bird, and R. Roth Antipsychotic drug action in schizophrenic patients: effect on cortical dopamine metabolism after long-term treatment Science, September 28, 1979; 205(4413): 1405 - 1407. [Abstract] [PDF]

				J. Barchas, H Akil, G. Elliott, R. Holman, and S. Watson Behavioral neurochemistry: neuroregulators and behavioral states Science, May 26, 1978; 200(4344): 964 - 973. [Abstract] [PDF]

				P. Groves, C. Wilson, S. Young, and G. Rebec Self-inhibition by dopaminergic neurons Science, November 7, 1975; 190(4214): 522 - 528. [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 1973 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us