Depot Phenothiazine Treatment in Acute Psychosis: A Sequential Comparative Clinical Study
CHING-PIAO CHIEN M.D.1, and
JONATHAN O. COLE M.D.2
1 Director of Clinical Research, Boston State Hospital, Boston, Mass. 02124 and Assistant Clinical Professor of Psychiatry, Tufts University School of Medicine, Boston, Mass.
2 Superintendent, Boston State Hospital, Boston, Mass. 02124 and Professor of Psychiatry, Tufts University School of Medicine, Boston, Mass.
In a study of the relative efficacy of three drug treatments for 46 newly hospitalized acutely psychotic patients, fluphenazine enanthate, alone or in combination with chlorpromazine, proved significantly more effective than chlorpromazine alone. Although fluphenazine enanthate, alone or in combination, produced more extrapyramidal side effects than chlorpromazine alone despite prophylactic antiparkinsonian medication, additional antiparkinsonian medication adequately controlled these side effects.
