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Am J Psychiatry 129:44-47, July 1972
doi: 10.1176/appi.ajp.129.1.44
© 1972 American Psychiatric Association
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Lithium Response in Unipolar Versus Bipolar Depression

FREDERICK K. GOODWIN M.D., DENNIS L. MURPHY M.D., DAVID L. DUNNER M.D.1, , and WILLIAM E. BUNNEY JR. M.D.2

1 New York State Psychiatric Institute, New York, N.Y.
2 Director, Division of Narcotic Addiction and Drug Abuse, NIMH

The antidepressant effects of lithium carbonate were evaluated in a group of 52 hospitalized depressed patients, using a longitudinal double-blind design that involved alternating drug and placebo periods in the same patient. Thirty-six of the 52 patients showed some improvement on lithium, including 15 who had complete remission of symptoms. Virtually all of the antidepressant responses occurred in patients with a past history of mania or hypomania (the bipolar group).




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