The Safety of a Single Daily Dose Schedule for Imipramine
KISHORE SARAF M.D., LL.B., D.P.M.1, and
DONALD F. KLEIN M.D.2
1 Resident in Psychiatry, Research Department, Hillside Hospital, 75-59 263rd St., Glen Oaks, N.Y. 11004
2 Director of Research, Hillside Hospital, 75-59 263rd St., Glen Oaks, N.Y. 11004
One reason for the traditional administration of medication in divided doses is that this is assumed to be safer than administration in single doses. The authors' analysis of clinical and laboratory data from 43 adult patients supports the view that imipramine hydrochloride may safely be given in a single nightly dose.
