The Reversal of Anticholinergic Drug-Induced Delirium and Coma with Physostigmine

doi:10.1176/appi.ajp.127.8.1050

Am J Psychiatry 127:1050-1054, February 1971
doi: 10.1176/appi.ajp.127.8.1050
© 1971 American Psychiatric Association



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	Articles by HEISER, J. F.
	Articles by GILLIN, J. C.

The Reversal of Anticholinergic Drug-Induced Delirium and Coma with Physostigmine

JON F. HEISER M.D.¹, and JOHN C. GILLIN M.D.²

¹ Staff Psychiatrist, U. S. Naval Hospital, Oakland, Calif. 94627
² Clinical Associate, National Institute of Mental Health, Bethesda, Md. 20014

Although its use for this purpose is not well recognized, physostigmineprovides an effective and safe treatment for delirium and comacaused by anticholinergic agents such as atropine, scopolamine,and hyoscyamine. The authors summarize the supporting evidenceand outline a recommended procedure.

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