Digital Computer Analyzed Sleep and Resting EEG During Haloperidol Treatment
TURAN M. ITIL M.D.1,
PATRICK GANNON M.D.2,
WILLIAM HSU M.S.3, , and
HELEN KLINGENBERG 4
1 Professor and associate chairman, and director, section of psychopharmacology, department of psychiatry, University of Missouri School of Medicine, Missouri Institute of Psychiatry, 5400 Arsenal St., St. Louis, Mo. 63139
2 Instructor of psychiatry, department of psychiatry, University of Missouri School of Medicine, Missouri Institute of Psychiatry, 5400 Arsenal St., St. Louis, Mo. 63139
3 System analyst and statistician, department of psychiatry, University of Missouri School of Medicine, Missouri Institute of Psychiatry, 5400 Arsenal St., St. Louis, Mo. 63139
4 Chief EEG technologist in the sleep lab, department of psychiatry, University of Missouri School of Medicine, Missouri Institute of Psychiatry, 5400 Arsenal St., St. Louis, Mo. 63139
The authors studied the effects of haloperidol on resting and all-night sleep EEGs of chronic schizophrenic patients. There was a decrease in slow waves and an increase in fast activity during resting and sleep EEGs as well as a decrease in the time spent in deep sleep stages during sleep. The findings support the hypothesis that compounds that are most effective with chronic schizophrenic patients have both central inhibitory and stimulating components.
