A Double-Blind Comparison of Lithium and Chlorpromazine in the Treatment of Manic States
GOTTFRIED SPRING M.D.1,
DANIEL SCHWEID M.D.2,
CARL GRAY M.D.3,
JOEL STEINBERG M.D.2, , and
MARC HORWITZ M.D.4
1 Teaching fellow, department of psychiatry, University Hospitals of Cleveland, Ohio 44106
2 Residents, department of psychiatry, University Hospitals of Cleveland, Ohio 44106
3 Psychiatric Institute, Washington, D. C.
4 United States Air Force
Lithium, at a dosage of 1,800 mg. daily, was found to be effective in the treatment of acute manic states. However, when compared with chlorpromazine by means of a double-blind technique using stringent diagnostic criteria, no significant difference between the two drugs was noted. In regard to the prophylactic effect of lithium, the data presented indicate that this question is still unresolved.
