Diphenylhydantoin in Neurotic Anxiety
WARREN G. CASE M.D.1,
KARL RICKELS M.D.2, , and
STANFORD BAZILIAN M.D.3
1 Research psychiatrist, Philadelphia General Hospital, 34th St. and Civic Center Blvd., Philadelphia, Pa. 19104
2 Director of the psychopharmacology unit, Philadelphia General Hospital, 34th St. and Civic Center Blvd., Philadelphia, Pa. 19104
3 Administrator for psychiatry, Philadelphia General Hospital, 34th St. and Civic Center Blvd., Philadelphia, Pa. 19104
Anxious-neurotic psychiatric clinic outpatients in social classes IV and V were treated over a four-week period with diphenylhydantoin, 100 mg., twice daily. While some improvement was observed in this patient group, no significant difference was noted between the diphenylhydantoin and a comparable placebo group.
