Urinary Adenosine 3', 5'-Monophosphate Excretion in Affective Disorders
MICHAEL L PAUL M.D.1,
BRUCE R. DITZION M.D.2,
GEORGE L. PAUK M.D.3, , and
DAVID S. JANOWSKY M.D.4
1 Laboratory of chemical pharmacology, National Heart Institute, bldg. 10, room 7N-l 19, Bethesda. Md. 20014
2 Department of medicine, Peter Bent Brigham Hospital, Boston. Mass.
3 Department of medicine, University of Texas, Medical Branch, Galveston, Tex.
4 Department of psychiatry, University of California at Los Angeles, Los Angeles. Calif., and Harbor General Hospital, Los Angeles, Calif.
The authors describe a measurement of 24-hour adenosine 3',5'-monophosphate (AMP) excretion in patients with affective disorders. Manic patients were fbund to have greater cyclic AMP excretions than normal controls. Severely depressed patients had lower 24-hour values than normal subjects and a lower 24-hour cyclic AMP excretion than moderately depressed individuals.
