DOM (STP), a New Hallucinogenic Drug, and DOET: Effects in Normal Subjects
SOLOMON H. SNYDER M.D.1,
LOUIS A. FAILLACE M.D.2, , and
HERBERT WEINGARTNER PH.D.3
1 Associate professor, department of psychiatry and the behavioral sciences, and associate professor, department of pharmacology and experimental therapeutics, Johns Hopkins University School of Medicine, Baltimore, Md. 21205
2 Associate professor of psychiatry, Johns Hopkins University School of Medicine, Baltimore, Md. 21205
3 Assistant professor of medical psychology, department of psychiatry and the behavioral sciences, Johns Hopkins University School of Medicine, Baltimore, Md. 21205
DOM, a hallucinogen related to mescaline and amphetamine and designated "STP" by hippies, along with DOET, the ethyl homologue of DOM, were given in small doses to normal subjects in a double-blind study. Both drugs increased self-awareness and produced mild euphoria but no hallucinogenic or psychotomimetic effects. The two drugs "freed up" subjects' word associations without impairing memory or concentration; in fact, DOM enhanced performance on serial learning tasks. Although DOM did not affect visual discrimination, it altered the perception of tachistoscopically presented TAT cards.
