Long-Term Chlorpromazine Retention and Its Modification by Steroids
MURRAY A. COWEN M.D.1, and
WILLIAM C. MARTIN 2
1 Clinical investigator and instructor in psychiatry, Veterans Administration Hospital, 800 Irving Ave., Syracuse, N. Y. 13210, and research consultant, Marcy State Hospital, Marcy, N. Y.
2 Senior laboratory technician, division of research, Marcy State Hospital
Urine chlorpromazine excretion was measured in 28 senile patients who had been unmedicated for 12 to 18 months. Significant amounts of chlorpromazine were often detectable. The excretion rate of chlorpromazine could be increased by administration of cortisone and decreased by administration of androgen.
