Possible Interaction Between Disulfiram and Isoniazid
H. G. WHITTINGTON M.D.1, and
LESLIE GREY M.D.2
1 Director of psychiatry, the Department of Health and Hospitals, West Sixth Ave. and Cherokee St., Denver, Colo. 80204
2 Private practice in Denver
In seven reported cases coordination difficulties and changes in affect and behavior developed following the concurrent administration of isoniazid and disulfiram. The authors suggest the possibility that these compounds, when administered in combination, may significantly alter metabolism of brain catecholamines.
