Serum Macroglobulin (S19) in Families of Monozygotic Twins Discordant for Schizophrenia
JAMES R. STABENAU M.D.1,
WILLIAM POLLIN M.D.1, , and
LOREN MOSHER M.D.2
1 Section on twin and sibling studies, Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Md. 20014
2 Assistant professor of psychiatry, Yale University Medical School, New Haven, Conn.
The authors studied 16 pairs of monozygotic twins—12 pairs of twins discordant for schizophrenia and four pairs of nonschizophrenic control twins—and their parents to determine the relationship between serum macroglobulin level and schizophrenia. They found no significant relation between the two factors. Evidence from these and other data suggests that serum macroglobulin levels are more influenced by factors based on sex and genetic makeup than by environment.
