A CLINICAL TRIAL OF ALPHA-METHYLDOPA IN ELATED STATES
LOREN R. MOSHER M.D.1,
GERALD L. KLERMAN M.D.2, , and
JOSEPH F. GREANEY M.D.
1 Clinical Associate, Section on Twin and Sibling Studies, National Institute of Mental Health, Bethesda, Md.
2 Associate Professor of Psychiatry, Yale University Medical School, New Haven, Conn.
A clinical trial of alpha-methyldopa (Aldomet) in elated states is reported. Four drug trials were conducted in three "manic" patients at dosage levels up to 6 gms. per day. No therapeutic effect was noted, although a pharmacologic effect as evidenced by a fall in blood pressure in three of four trials was noted. However, further studies with this compound in psychiatric patients are indicated before final conclusions can be drawn.
