Am J Psychiatry 120:458-464, November 1963
doi: 10.1176/appi.ajp.120.5.458
© 1963 American Psychiatric Association
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THE EFFECTS OF METHYLPHENIDATE ON SYMPTOMATOLOGy AND LEARNING IN DISTURBED CHILDREN
C. KEITH CONNERS PH.D.1, and
LEON EISENBERG M.D.2
1 Dept. of Psychiatry, Johns Hopkins University School of Medicine, Children's Psychiatric Service, The Harriet Lane Home, Johns Hopkins Hospital.
2 Dept. of Pediatrics, Johns Hopkins University School of Medicine, Children's Psychiatric Service, The Harriet Lane Home, Johns Hopkins Hospital.
This study investigated the effects of methylphenidate administered double-blind over a 10-day period to two groups of emotionally disturbed children (total N = 81). Symptom ratings by house parents and child care workers were obtained before treatment and on the last day of treatment. Total symptom scores were improved in the drug group at a statistically significant level. Changes in individual symptoms occurred mostly with outwardly directed symptoms such as "leads into trouble," and there were hints that anxiety showed an increase. The only adverse side effect was a high report (70%) of appetite loss in the drug group.
Objective measures of learning and maze performance also showed reliable improvement in the drug group, minimizing the possibility that symptom changes were due to rater biases. Questionnaire measures of initial level of anxiety and impulsivity were not related to symptomatic improvement in the drug group, and some doubt as to the validity of these instruments for the type of children studied was raised by the results.
The results agree with previous clinical studies and are interpreted as reflecting an activation of inhibitory controlling systems. The wide individual variation in response to the drug indicates further research on individual difference factors is required, as well as caution in the application of the drug in clinical situations.
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