MAO ACTIVITY IN RELATION TO DEPRESSION
AARON FELDSTEIN PH.D.,
HUDSON HOAGLAND PH.D., D.SC.,
KEITH KAM-KIM WONG M.S.,
MILAGROS RIVERA OKTEM M.D., , and
HARRY FREEMAN M.D.1
1 The Worcester Foundation for Experimental Biology, Shrewsbury, Mass., and Medfield State Hospital, Medfield, Mass.
Serotonin-C14 was administered orally to 22 depressed patients and 22 normal subjects. The recovery of 5-HIAA-C14 calculated on the basis of administered serotonin-C14 and adjusted for variations in total carbon-14 recovery showed no significant difference between the groups. It was concluded that MAO and aldehyde de-hydrogenase functioned normally in the depressed patients within the limitations imposed by the method.
