A COMPREHENSIVE METHOD FOR THE DETERMINATION OF URINARY CHLORPROMAZINE AND ITS OXIDATIVE METABOLITES
IRENE S. FORREST 1,
MAGDALENA BERGER WECHSLER 1, , and
JOSEPH E. SPERCO 1
1 Biochem. Research Lab., VA Hospital, Palo, Calif., Dept. Exp. Psychiatry, N. Y. State Psychiatric Institute, Food and Drug Administration, Boston, Mass.
1. A method for the determination of urinary chlorpromazine and its metabolites employing adsorption on Dowex 50 W-X4 cation exchange resin is described.
2. Polar, intermediary oxidative and conjugated metabolites constitute by far the largest drug fraction, amounting to approximately 80% of total urinary drug.
3. One half of administered daily drug doses was found to be excreted in the urine.
4. Recoveries by this method range from 88% to 97%.
