CHLORDIAZEPOXIDE AS ADJUNCTIVE THERAPY IN CONVULSIVE DISORDERS
SIDNEY MERLIS M.D.,
WILLIAM J. TURNER M.D., , and
SEYMOUR HALPERN PH.D.1
1 The clinical and laboratory facilities, Research Division, Central Islip State Hospital, Central Islip, N. Y.
Eighty-five of 86 patients starting treatment were evaluated. One patient after 5 days of treatment developed clinical jaundice and was discontinued from the series. Prior to treatment 76 of 85 patients (89%) had fair or poor control of seizures. Following the use of chlordiazepoxide 56 of 85 patients (66%) had fair or poor control. The dosage used was 10 to 60 mgm. daily. Chlordiazepoxide appears generally to be compatible with the currently available anticonvulsive agents. Undesirable side effects, such as somnolence, ataxia and vertigo, were mild and relatively insignificant except at the highest dose. In spite of this chlordiazepoxide appears to be an effective adjunctive treatment in seizure disturbances.
