THE EFFECT OF MP-809 IN DEPRESSIVE STATES: A MULTI-BLIND STUDY
H. AZIMA M.D.,
DOROTHY ARTHURS R.N.,
A. SILVER M.D., , and
FERN J. AZIMA M.A.1
1 McGill University, Dept. of Psychiatry, Allan Memorial Institute, Psychopharmacology Section.
1. A new substance, MP-809, a tryptamine derivative, was investigated in 50 depressed patients, as compared to two other groups of 50 depressed patients receiving inert and potent placebo, in a multiblind controlled setting.
2. Clinically MP-809 had a significant (marked to moderate) antidepressant activity in 52% of all patients and in 74.1% of neurotic depressions. Statistically the results were significantly in favour of MP-809 as compared with the two placebos, and this significance reached the high level of P<0.001 in neurotic depressions.
3. Side effects were frequent but minimal in their intensity.
4. The final conclusion was that MP-809 is a potent antidepressant agent particularly in neurotic depressive states.
