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Am J Psychiatry 119:464-465, November 1962
doi: 10.1176/appi.ajp.119.5.464
© 1962 American Psychiatric Association
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HISTAMINE-INDUCED VANIL-MANDELIC-ACIDURIA IN THE SCHIZOPHRENIC AND THE NON-SCHIZOPHRENIC PSYCHIATRIC PATIENT

PAUL KOCH PH.D., PIERRE LEFEBVRE M.D., ROGER LEMIEUX M.D., , and CAMILLE LAURIN M.D.1

1 Albert Prévost Institute, 6555 West Gouin Blvd., Montreal, Canada.

Intramuscular histamine can be used to confirm a diagnosis of schizophrenia in the young schizophrenic male. It will increase his urinary excretion of vanil-mandelic acid significantly. Histamine induced vanil-mandelic-aciduria will neither occur in the non-schizophrenic psychiatric male patient nor in any psychiatric woman patient, schizophrenic or not.







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