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Am J Psychiatry 117:1032-1033, May 1961
doi: 10.1176/appi.ajp.117.11.1032
© 1961 American Psychiatric Association
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IMPROVING INSULIN THERAPY WITH NEOSTIGMINE

AMEDEO ESPOSITO M.D., and IRVING D. ROSENBERG M.D.

In insulin coma therapy, in those patients who regularly require intravenous injections of glucose to bring them out of coma, the intramuscular injection of 1 or 1frac12 mg. of neostigmine from 10 to 45 minutes before gavage with 1 quart of 40% sucrose resulted in a 100% elimination of intravenous injections required. This therefore is felt to be an important contribution to insulin coma therapy. In addition it may help materially in the re-establishment of insulin coma therapy at those mental hospitals where it was previously discontinued because of the greater number of personnel required to administer intravenous injections.







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