THRESHOLDS FOR DRUG-INDUCED AKATHISIA
DANIEL X. FREEDMAN M.D.1, and
JACOB DE JONG M.D.2
1 Assistant Professor of Psychiatry, Psychopharmacology Laboratory, Departments of Psychiatry and Pharmacology, School of Medicine, Yale University, New Haven, Conn.
2 Physician and Psychiatrist, Fairfield State Hospital, Newtown, Conn.
The findings indicate that low-dose akathisia results from an individual's specific sensitivity to a specific molecular configuration. There is a population with a low threshold for the disorder. Thresholds are determined by the spectrum of individual sensitivities for specific molecular configurations, administered in a specified dosage schedule. The incidence and intensity of low-dose akathisia depend on at least 2 factors: the population tested, and specific molecular structure. [SEE TABLE 1 IN SOURCE PDF]
