ADJUVANT THERAPY WITH ISOCARBOXAZID
STANLEY R. DEAN M.D.
In this series of 47 patients with a variety of depressive reactions, isocarboxazid produced a fair to excellent effect in 63.8% overall, and in 26 of the 27 reactive depressives and schizophrenic apathetics. Although it did not eliminate nor reduce the need for ECT, it was a valuable adjunct to ECT and intensive psychotherapy, particularly in reactive depressions. While not found quite as effective as iproniazid, it was definitely better tolerated and less toxic, with no clinical evidence of hepatoxicity in any of the patients.
