A GRAPHIC COMPARISON OF FIVE PHENOTHIAZINES
JACKSON A. SMITH M.D.1,
DOROTHY CHRISTIAN R.N.2,
ELAINE MANSFIELD R. N.3, , and
ALFREDO FIGAREDO M.D.3
1 Professor of Neurology and Psychiatry, Univ. of Neb. College of Medicine, Associate Director for Research, Neb. Psychiatric Inst., Omaha, Neb.
2 Research Nurse, Norfolk State Hosp., Norfolk, Neb.
3 Chief Research Nurse, and Resident, Nebraska Psychiatric Institute, Omaha, Neb.
Five phenothiazine derivatives have been studied using similar groups of patients and similar methods of evaluating and recording behavioral change. All of the patients included in these reports had been hospitalized longer than one year and had been refractory to previous treatment efforts.
The results indicate that this group of chronic patients, all but 3 of whom were schizophrenic, were no more responsive to these compounds than to treatment procedures earlier tried. The graphing of the data simplifies the comparison of compounds evaluated under similar conditions.
Improvement occurred so infrequently in these screening procedures that a controlled or "double-blind" study did not appear necessary.
