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Am J Psychiatry 113:115-121, August 1956
doi: 10.1176/appi.ajp.113.2.115
© 1956 American Psychiatric Association
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COMPLICATIONS OF CHLORPROMAZINE THERAPY

IRVIN M. COHEN M. D.1

1 Associate professor of neurology and psychiatry, University of Texas Medical Branch, Galveston.

1. Chlorpromazine has many undesirable effects, most of which are transient and of relatively minor clinical significance.

2. Complications of greater severity occur in a significant number of cases but generally resolve rapidly and without residuals.

3. Four categories of complications are distinguishable: direct or indirect action on various levels of the nervous System, allergic-type reactions, responses of indefinite origin, and indirect effects of drug action.

4. Despite its numerous undesirable effects chlorpromazine is clinically a relatively safe drug.







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