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Am J Psychiatry 112:788-794, April 1956
doi: 10.1176/appi.ajp.112.10.788
© 1956 American Psychiatric Association
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CLINICAL AND ELECTROENCEPHALOGRAM INVESTIGATION ON LARGACTIL IN PSYCHOSIS (PRELIMINARY STUDY)

A. SZATMARI M. D.

1. Experimental investigations have been carried out with Largactil on chronic and acute mental patients.

2. The over-all improvement in chronic cases was 69% and in acute cases 60%.

3. However, the transitory effects in acute cases indicate that while Largactil is extremely valuable in chronic psychosis, in acute psychotic breakdowns, it has value only as a sedative.

4. Electroencephalogram investigations showed that Largactil markedly decreases the muscle artefacts, decreases the frequency, and increases the voltage, causing a mild progressive synchronization and, in epileptics, it lessens the convulsive threshold.

5. In spastics it decreases spasticity through intravenous route, as tested by electromyogram.







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