0
Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

1
Letters to the Editor   |    
Dr. Hirschfeld Replies
ROBERT M.A. HIRSCHFELD
Am J Psychiatry 2006;163:1839-1839.
text A A A

To the Editor: The letter by Drs. Moreira-Almeida and Pietrobon casts doubt on whether olanzapine monotherapy is efficacious for treatment of bipolar depression. The authors acknowledge that olanzapine monotherapy was associated with a statistically significant drop in the Montgomery-Asberg Depression Rating Scale score over 8 weeks compared with placebo. Most of this drug/placebo difference was due to improvement in sleep and increased appetite, which are known side effects of olanzapine. Olanzapine monotherapy was not associated with improvement in core symptoms of depression, including depressed mood.

My professional opinion is in agreement with the position that olanzapine monotherapy is of limited utility in treating bipolar depression. I believe the efficacy of olanzapine-fluoxetine combination is well established and is reflected in the fact that eight of the 10 Montgomery-Asberg Depression Rating Scale items showed improvement over placebo.

I do take issue with the assertion that the APA Guideline Watch for the Treatment of Patients with Bipolar Disorder claimed “the efficacy associated with olanzapine or olanzapine plus fluoxetine in the treatment of bipolar depression.” In the Guideline Watch, the results of the study were presented, but no claim to efficacy was made.

+

References

+
+

CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe



Related Content
Books
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 9.  >
APA Practice Guidelines > Chapter 7.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 12.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 2.  >
The American Psychiatric Publishing Textbook of Psychopharmacology, 4th Edition > Chapter 54.  >
Topic Collections
Psychiatric News
APA Guidelines
PubMed Articles