Chapter 12 is on brain-related health care new models for personalized medicine in psychiatry. It highlights the fact that better clinical outcomes with personalized medicine should lead to better financial outcomes. Chapter 14, on the economic impact of the personalized medicine tsunami, is—as suggested by its title—provocative yet thoughtful. The authors point out that we are in the middle of dramatic changes in health care, including the availability of new technologies combined with new public attitudes and public policies. The authors address the "four Ps" of research of the National Institutes of Health: predictive, personalized, preemptive, and participatory, namely, that the "participation" of a diverse group of people in diverse settings is needed in order to increase our capacity to "predict" who is at risk in order to develop new therapies to "preempt" the development of disease by using "personalized" interventions. The authors also address challenges of new policies, such as the Mental Health Parity and Addiction Equity Act of 2008, which, in order to succeed, will need to be accompanied by new treatment solutions to fulfill the demand of the expanded coverage.