Links between schizophrenia and autoimmune disorders, such as celiac disease, Sjogren’s syndrome, and type 1 diabetes, have been tantalizing but inconsistent. Population-based evidence now comes from Eaton et al. p. 521), who paired a Danish schizophrenia register with hospitalizations for 29 autoimmune diseases. The 7,704 schizophrenia patients admitted to psychiatric facilities between 1981 and 1998 had a nearly 50% higher prevalence of one or more autoimmune disorders than did matched comparison subjects. Five diseases were more prevalent in both the schizophrenia patients and their parents: thyrotoxicosis, intestinal malabsorption, acquired hemolytic anemia, interstitial cystitis, and Sjogren’s syndrome. These epidemiological findings confirm several previously reported associations between schizophrenia and autoimmune disorders and may eventually steer research to common etiologic pathways.