ECG recordings in fluoxetine preregistration trials (N=312) showed no heart-block-inducing ECG conductance disturbances. However, four case reports implicating fluoxetine in QTc prolongation (2, 3) or torsades de pointes (4, 5) have been published. One involved intentional overdose (5), and one involved concomitant verapamil treatment (3). Because of fluoxetine’s widespread use, the absence of cardiac conductance disturbances in the limited relatively healthy population in the preregistration phase is not very informative. However, at postregistration, thousands of ECG recordings in patients taking fluoxetine have been performed; in two studies focused on those with heart disease, no conduction disturbances were recorded. In our patient, there was a suggestive temporal relationship between the use of fluoxetine and the occurrence of QT prolongation and repeated episodes of torsades de pointes. After withdrawal of fluoxetine, the QTc interval returned to normal. In the absence of other plausible explanations, we conclude that the use of fluoxetine was the probable cause of the development of recurrent torsades de pointes. Older age, preexistent left bundle branch block, and female gender were likely additional risk factors (1).