This manual is an excellent and comprehensive review of current knowledge on the psychopharmacology of addictive disorders. It consists of 10 chapters; nine address one class of substances each, and the tenth focuses on psychosocial treatments. Chapters are written by experts with extensive backgrounds in addiction treatment and research and include sections on the history and epidemiology of addictive disorders, diagnosis, pharmacokinetics, pharmacodynamics, neuropharmacology, treatment outcome, and other topics of interest to clinicians, researchers, administrators, and students. Extensive reference lists are found at the end of each chapter and include the most current as well as some of the older, important studies, with a few reaching back into the 1950s and 1960s. The chapter on psychosocial treatments is OK but does not have the depth and breadth of the others; it does not provide much historical information and misses points on therapist differences, psychiatric severity, the impact of the control condition on study outcome, the value of drug counseling, and the role of these treatments in HIV risk reduction.