First, the study group in the article by Dr. Schuckit et al. was rather unusual, with more than 70% of the subjects being relatives of treatment-seeking alcoholics. This limited the generalizability of their findings. For example, in our recent study of a large general population sample (N=7,076) (3), subjects with a DSM-IV diagnosis of alcohol abuse could not be differentiated from subjects without a DSM-IV alcohol use disorder diagnosis with a broad range of external validators (e.g., psychiatric comorbidity, functional status, familial alcohol problems, treatment seeking). Subjects with two or more criteria, however, were significantly different from subjects without a DSM-IV alcohol use disorder, indicating better validity for a threshold of at least two criteria (3).