Overall, the trial highlights the present sorry state of research into antidepressant efficacy. A more rigorous view of the data by site suggests that the trial lacked ecological validity. When rates of response and remission are higher for placebo than for active drug at six of nine sites (the authors’ Figure 2), the pooled analysis becomes an exercise in futility. Moreover, the faintly encouraging secondary analyses lacked a sound base in any primary effect, and they were not corrected for multiple comparisons. These concerns are compounded by the multivariate statistical approach, which inflated the practical significance of the secondary analyses.