Functional imaging data were acquired on a 1.5-T system in 13 right-handed, male schizophrenia (DSM-IV) patients, each studied twice, with written informed consent and ethics committee approval. Patients with first-rank symptoms (N=7) (age: mean=36 years, SD=11; illness duration: mean=15 years, SD=11; premorbid IQ: mean=102.1, SD=9.7; chlorpromazine equivalents: mean=507.1 mg/day, SD=255.7; extrapyramidal symptom score: mean=5.6, SD=10.5) were comparable with those without first-rank symptoms (N=6) (independent-sample t test, df=11, p>0.05 on all measures). The patients performed spontaneous, freely timed movements using their right index finger in an event-related fMRI paradigm (5). Images were analyzed by using a random-effects model in statistical parametric mapping. The validity of the parametric results was examined with nonparametric permutation tests. We examined the response latency in left Brodmann’s area 4 and right Brodmann’s area 40 by using time to half-maximum blood-oxygen-level-dependent response as a measure of latency (5).