Received April 29, 2004; revision received Oct. 25, 2004; accepted Oct. 29, 2004. From the Center for Advanced Brain Imaging, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, N.Y.; the Department of Psychiatry, New York University School of Medicine, New York; the Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Medical System—Brockton Division, Harvard Medical School; the Cognitive Neuroscience Laboratory, McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, Mass.; the Psychiatry and Behavioral Science Imaging, Surgical Planning Laboratory, MRI Division, Department of Radiology, Brigham & Women’s Hospital, Harvard Medical School, Boston; and Georgetown University School of Medicine, Washington, D.C. Address correspondence and reprint requests to Drs. Shenton and McCarley, Department of Psychiatry-116A, Boston VA Healthcare System—Brockton Division, Harvard Medical School, 940 Belmont St., Brockton, MA 02301; firstname.lastname@example.org or email@example.com (e-mail). Supported by an Ethel Dupont-Warren Fellowship, Department of Psychiatry, Harvard Medical School (Dr. Nierenberg), the Department of Veterans Affairs (VA Merit Awards [Dr. Shenton and Dr. McCarley] and a REAP Award [Dr. McCarley]), the MIND Institute (Dr. McCarley), and NIMH grants K02 MH-01110, R01 MH-50747 (Dr. Shenton), and R01 MH-40799 (Dr. McCarley). The authors thank Drs. Chandlee Dickey and Melissa Frumin for helpful advice on methodology and Aleksandra Ciszewski and Sarah Toner for technical assistance.