Second, the vast majority of patients in both groups were treated with lorazepam in addition to the antipsychotic. Why were such high rates of lorazepam allowed? Granted, acutely psychotic patients often benefit from a benzodiazepine. But because a major goal of the study was to compare the efficacy of ziprasidone versus olanzapine, then the high rate of use of lorazepam limited the interpretation of the results. Benzodiazepines help to enhance sleep and reduce agitation and anxiety, thus interfering with the interpretations regarding efficacy of the antipsychotics. Furthermore, benzodiazepines suppress antipsychotic-induced movement disorders such as akathisia, thus limiting the interpretation of the results regarding these adverse events.