The editors and chapter authors of the Handbook of Clinical Alcoholism Treatment set out to provide a comprehensive, easily accessible review addressing crucial issues in the understanding of the disease of alcoholism. They have accomplished this with extraordinary attention to detail in what has morphed into a mini-textbook rather than a cursory review or handbook. For primary care providers and addiction specialists, this resource provides extensive epidemiological, neurobiological, psychological, and sociocultural knowledge relevant to the understanding and successful treatment of patients suffering from alcoholism. Alcoholism is defined as a primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. Often progressive and fatal, it is characterized by periodic or continuous impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions of thinking, most notably denial. The multifaceted etiology and natural course of alcoholism mandate a broad-based understanding and multidisciplinary approaches to assessment and treatment.