Briefly looking at three of the chapters will help to understand the broader focus of the book. The first chapter, "Principles of Neurobehavioral Teratology," presents a brief overview of current teratology and 10 basic principles of research in this area. These principles include possible mechanisms of effect, likely agents, exposure, dose-response relationships, and timing effects. The chapter ends, as many do, with a section titled Future Directions. Chapter 9, "Early Orbitofrontal-Limbic Dysfunction and Autism," discusses aspects of social and other behaviors, links them to neural structures and circuits, and proposes related deficits in autistiform behaviors. Finally, chapter 21, "Neurohormonal Aspects of the Development of Psychotic Disorders," is a broadly written chapter that includes, among other topics, important background information, behavioral and biological risk indicators, and a view on the synthesis of the early developmental course of psychosis. Again, this chapter finishes with perspectives on future research topics.