Third is the questionable efficacy of mifepristone in psychotic depression in contrast to Dr. Rothschild’s statement of its use in "rapidly reversing psychotic major depression." In the two published studies on this issue, there was no significant drug effect (1, 8). In the first study (8), two placebo cells were eliminated because they were considered a drug carryover effect, and an independent-samples analysis apparently was performed, even though the data were paired (subjects were their own control subjects). My independent, paired-data analysis yielded a clearly nonsignificant difference. In the second study, no statistical analysis at all was presented. My analysis of those outcome data again yielded a clearly nonsignificant difference. As well, the April 2004 initial public offering filed with the Securities and Exchange Commission by Corcept Therapeutics (9) indicates that even in large double-blind trials, only a small number of patients became asymptomatic, with no significant difference between drug and placebo. Does this medication, then, warrant the paean of "ECT in a bottle" (10)?