This book examines, in a broadly defined way, the work of Brendan A. Maher, Ph.D., the Edward C. Henderson Professor of the Psychology of Personality, Department of Psychology, Harvard University. For those unfamiliar with Dr. Maher’s work, he is a primary architect of experimental psychopathology, a leading scholar in schizophrenia research, a teacher and mentor of many, and an academic statesman-at-large. The book is a Festschrift, referring directly to Brendan Maher’s methodological contributions to the study of mental illness and alluding to his landmark book on the topic (1), supported in part by the American Psychological Association Science Conference and the Decade of the Brain series.