To the Editor: The conclusions of Dr. Jorge and colleagues regarding the association between use of antidepressants and all-cause mortality following stroke are suspect because of the possibility of uncontrolled confounding. The authors reported that the association between antidepressant use and mortality remained significant after they controlled for age, stroke type, diabetes mellitus, and relapsing depression in a logistic regression model. However, there are other variables (reported in their Table 1), such as marital status, which were associated with treatment group and mortality and might therefore confound the association between treatment group and mortality. In addition, there are variables that are associated with mortality (reported in their Table 4), such as obesity and atrial fibrillation, which might confound the association if they were also associated with treatment group. The only variables that were included in the logistic model were those that were associated with treatment group and outcome (mortality) at the p<0.05 level.