Received July 20, 2003; revision received Oct. 17, 2003; accepted Nov. 7, 2003. From the Psychiatric Hospital at Vanderbilt University, Nashville, Tenn.; and CNS Clinical Development, Sanofi-Synthelabo Research, Malvern, Pa., and Chilly-Mazarin, France. Address reprint requests to Dr. Arvanitis, CNS Clinical Development, Sanofi-Synthelabo Research, 9 Great Valley Parkway, Malvern, PA 19355; lisa.arvanitis@ sanofi-synthelabo.com or firstname.lastname@example.org (e-mail). Supported by Sanofi-Synthelabo Research. Dr. Meltzer has received grant support from and is a consultant to Acadia, AstraZeneca, Eli Lilly, GlaxoSmithKline, Janssen Pharmaceutica, Lundbeck, Novartis, Pfizer, Sanofi-Synthelabo, and Solvay. He is a consultant to Psychiatric Genomics, Precision Med, Pharmacia, and Roche. Drs. Arvanitis and Rein and Ms. Bauer are employees of Sanofi-Synthelabo. The authors thank Amir Khalali, M.D. (medical monitor), and the staff of Quintiles Pacific, Inc., as well as Ms. Valerie Stella (clinical trial manager), Ms. Susan Black (data manager), Katherine Coulouvrat, M.D. (Pharmacovigilance), and Ms. Christine Beerland (Pharmacovigilance) of Sanofi-Synthelabo Research. The Meta-Trial Study Group was composed of the following collaborating investigators and sites: Adityanjee, M.D. (University Hospitals of Cleveland); Asaf Aleem, M.D. (Charter Peachford Behavioral Health System, Atlanta); Saide Altinsan, M.D. (Pharmacology Research Clinic, Reno, Nev.); Mohammed Bari, M.D. (Chula Vista, Calif.); Nigel Bark, M.D. (Bronx Psychiatric Center, Bronx, N.Y.); Bijan Bastani, M.D. (Beachwood, Ohio); Raymond Bland, M.D. (Southern Illinois University School of Medicine, Springfield); Jeffrey Borenstein, M.D. (Holliswood Hospital, Holliswood, N.Y.); David Brown, M.D. (Community Clinical Research, Austin, Tex.); Jose Canive, M.D. (Veterans Affairs Medical Center, Albuquerque, N.Mex.); John Carman, M.D. (Smyrna, Ga.); Franca Centorrino, M.D. (McLean Hospital, Belmont, Mass.); Charles Charuvastra, M.D. (Mission Community Hospital, San Fernando, Calif.); Stanley Cheren, M.D. (MetroWest Medical Center, Natick, Mass.); John Csernansky, M.D. (Washington University School of Medicine, St. Louis); Andrew Cutler, M.D. (Coordinated Research of Florida, Inc., Winter Park, Fla.); David Daniel, M.D. (ICSL-Clinical Studies, Falls Church, Va.); Michael DePriest, M.D. (Pharmacology Research Corporation, Las Vegas); Deepak D’Souza, M.D. (Veterans Affairs Medical Center, West Haven, Conn.); Larry Ereshefsky, Pharm.D. (San Antonio State Hospital, San Antonio, Tex.); Louis Fabre, M.D., Ph.D. (Houston); David Feifel, M.D., Ph.D. (Department of Psychiatry, University of California at San Diego Medical Center); Arthur Freeman III, M.D. (Louisiana State University Health Science Center, Shreveport); Clifford Goldman, M.D. (ClinSearch, Inc., Summit, N.J.); Thomas Hansen, M.D. (Veterans Affairs Medical Center, Portland, Ore.); James Hartford, M.D. (Hartford Research Group, Cincinnati); Robert Hirschfeld, M.D. (University of Texas Medical Branch, Galveston, Tex.); Richard Jaffe, M.D. (Belmont Center for Comprehensive Treatment, Philadelphia); Jasbir Kang, M.D. (Western Pennsylvania Psychiatric Center, Center Township, Pa.); Jeffrey Klopper, M.D. (Atlanta Psychiatry and Neurology, Smyrna, Ga.); Mary Ann Knesevich, M.D. (Dallas); Ronald Landbloom, M.D. (Regions Hospital, St. Paul); Michael Lesem, M.D. (Bellaire, Tex.); Robert Levine, M.D. (New York); Robert Litman, M.D. (Centers for Behavioral Health, Rockville, Md.); Edward Logue, M.D. (Birmingham Psychiatry Pharmaceutical Studies, Inc., Birmingham, Ala.); Adam Lowy, M.D. (Psychiatric Institute of Washington, Washington, D.C.); Stephen Marder, M.D. (Veterans Affairs Medical Center, West Los Angeles); Joseph McEvoy, M.D. (John Umstead Hospital-AAU, Butner, N.C.); Thomas McLaughlin, M.D. (Northeast Clinical Trials, Inc., Lawrence, Mass.); Herbert Meltzer, M.D. (Psychiatric Hospital at Vanderbilt, Nashville, Tenn.); Norman Moore, M.D. (Macon, Ga.); Gregory Oxenkrug, M.D., Ph.D. (St. Elizabeth’s Medical Center, Brighton, Mass.); Dennis Pavlinac, M.D. (Oceanside, Calif.); Richard Pearlman, M.D. (Sisters of Charity Medical Center, St. Vincent’s Campus, Staten Island, N.Y.); Steven Potkin, M.D. (University of California Irvine Medical Center, Orange); Jeffrey Rausch, M.D. (Medical College of Georgia, Augusta); Neil Richtand, M.D., Ph.D. (Veterans Affairs Medical Center, Cincinnati); Dennis Riff, M.D. (Advanced Behavioral Research Institute, Anaheim, Calif.); Samuel Risch, M.D. (Medical University of South Carolina, Charleston); Judy Rivenbark, M.D. (Charter By the Sea, St. Simons Island, Ga.); Murray Rosenthal, D.O. (Behavioral and Medical Research, San Diego); David Sack, M.D. (Institute for Psychopharmacology Research, Cerritos, Calif.); Steven Schwarzkopf, M.D. (Rochester, N.Y.); Joyce Small, M.D. (Larue D. Carter Memorial Hospital, Indianapolis); Steve Targum, M.D. (ICSL-Clinical Studies, Philadelphia); Cherian Verghese, M.D. (Albert Einstein Medical Center, Philadelphia); Jan Volavka, M.D. (Nathan S. Kline Institute for Psychiatric Research, Orangeburg, N.Y.); Scott West, M.D. (Psychiatric Institute of Florida, Orlando); John Zajecka, M.D. (Rush-Presbyterian-St. Luke’s Medical Center, Chicago); Daniel Zimbroff, M.D. (Pacific Clinical Research, Upland, Calif.).