In the first section they review the models and paradigms that have guided treatment and rehabilitation in the past. They consider that the medical model, which preceded and later succeeded the psychoanalytic one, is not adequate because it primarily addresses the neurophysiology of mental illness through pharmacotherapy. Symptom relief through the administration of medications can restore premorbid functioning to a degree and may be sufficient in some individuals, but optimal, effective, and lasting rehabilitation for most cases of schizophrenia, for example, must address all deficits in functioning. The new paradigm is integration of assessments of and interventions at the neurocognitive, social-cognitive, and sociobehavioral levels of functioning in addition to the neurophysiological.