Seven patients (four men and three women) with a paranoid-hallucinatory (N=3) or schizoaffective psychosis (diagnosed according to DSM-III-R) gave written informed consent to be treated with clozapine combined with amisulpride. Their mean age was 41.3 years (SD=7.9, range=32–54). In the preceding 12–72 months, each had received neuroleptics from at least three different classes (butyrophenone, thioxanthene, and phenothiazine); in four cases, ECT was also applied. Since no significant improvement had occurred, all patients had been given monotherapy with clozapine; the average length of treatment was 30 weeks (range=8–52). With clozapine (an average dose of 293 mg/day), there was also no significant clinical improvement.