Finally, we have three "pet peeves" (not intended to dissuade anyone from a wise decision to acquire a copy of the book). First, for those able to recall from their training years the quick reference handbooks that would fit in the pocket of a white coat, this large tome, which did not fit vertically into my standard VA hospital bookshelf, is more of a desk reference than a handbook. Second, physicians, especially those in primary care, may not be entirely comfortable with the emphasis on psychological and behavioral treatments; psychopharmacologic interventions are touched on throughout the book, but only one of nine chapters, "Pharmacotherapy for Smoking Cessation," specifically addresses the topic. Lastly, the terms "nicotine addiction," "nicotine dependence," "tobacco addiction," "tobacco dependence," "smoking behavior," and "smoking" are intentionally used interchangeably "to reflect the powerful biobehavioral mechanisms underlying nicotine addiction." The problem with this blurring of terminology is that exogenous smokeless nicotine, despite its tendency to induce dependency, is likely, in the near future, to find clinical uses in the treatment of one of several conditions for which it is being studied, including ulcerative colitis, schizophrenia, bipolar disorder, Parkinson’s disease, Alzheimer’s disease, and Tourette’s syndrome. In fact, in 2001 one of us reviewed another excellent book summarizing the very promising research in these areas (1). We hope that others will find this handbook as valuable as we and our residents have, so that the current printing will sell out quickly, allowing later editions to reflect the likely or, by that time, demonstrated usefulness of smokeless nicotine outside of smoking cessation treatment and remove the guilt by association.