When it first appeared, The Biochemical Basis of Neuropharmacology was the only book of its kind, and it filled the void with aplomb. As the authors note in their introduction to the current edition, the field has exploded beyond any of our most optimistic predictions. There now exists a myriad of worthy challengers—large textbooks, manuals, books designed for graduate-level courses in neuroscience and/or pharmacology—and some are quite good. Very few, however, if any, are as good as this volume. In 400 pages, it provides the novice (undergraduate and graduate students, resident physicians, fellows) and the interested specialist in another field a very readable and understandable summary of a broad array of neuroscience—not just neuropharmacology but also molecular and cellular neurobiology. The new cover is surely the most attractive of any of the previous editions. After five introductory chapters that constitute approximately one-quarter of the book, six chapters with a focus on one of more neurotransmitters follow. The final two chapters are concerned with cellular mechanisms in learning and memory and treating neurological and psychiatric diseases.