Received Aug. 8, 2002; revision received Dec. 27, 2002; accepted Jan. 6, 2003. From the Departments of Psychiatry and Diagnostic Radiology and the Yale Child Study Center, Yale University School of Medicine, New Haven, Conn.; the Mood and Anxiety Research Program, NIMH, Bethesda, Md.; and the Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York. Address reprint requests to Dr. Blumberg, Department of Psychiatry 116A, VA Connecticut Healthcare System, 950 Campbell Ave., West Haven, CT 06516; firstname.lastname@example.org (e-mail). Supported by grants from the Stanley Medical Research Institute, the National Alliance for Research on Schizophrenia and Depression, and the Ethel F. Donaghue Women’s Investigator Program at Yale (Dr. Blumberg); from the Charles A. Dana Foundation and the Suzanne Crosby Murphy Endowment at Columbia University College of Physicians and Surgeons (Dr. Peterson); from the Department of Veterans Affairs (Dr. Blumberg and Dr. Kaufman); and from the NIMH Mental Health Clinical Research Center program (Dr. Blumberg, Dr. Charney, and Dr. Kaufman); NIMH grants MH-01232 and MH-59139 (Dr. Peterson) and MH-01792 (Dr. Martin); and grant AA-00261-01 from the National Institute on Alcohol Abuse and Alcoholism (Dr. Kaufman). The authors thank Kathleen Colonese for expert care in coordinating the research, Nianjun Liu and Ralitza Gueorguieva for statistical consultation, Heather Douglas-Palumberi and Mindy Crouse-Artus for assistance in working with the adolescent research subjects, Hedy Sarofin and Terry Hickey for technical assistance, and the research subjects and their families for their participation.