Dr. Rifkin also concludes—erroneously in our view—that the study by Mynors-Wallis et al. (1995) "does not address the comparison of psychotherapy to drug treatment since the most relevant comparison (at 6 weeks) showed no drug effect for a well-proven drug treatment." First, that study showed amitriptyline to be superior to placebo at 6 weeks on the basis of another analysis comparing mean scores on the Hamilton depression scale before and after 6 weeks of treatment. Second, the remission rates at 6 weeks (29% for subjects taking amitriptyline versus 3% for subjects taking placebo), although not significantly different (the groups were small), were clearly clinically meaningful. Finally, the results at 12 weeks consistently showed that both amitriptyline and problem-solving therapy were superior to placebo but not significantly different from each other.